D. Research Applications:

1. Recognition of DNA structure using chiral metal chelates:
Research by Jacqueline K. Barton and Douglas C. Rees,
California Institute of Technology

b. The Crystal Structure of two oligomers of B-DNA with five intercalated molecules of Δ-α-[Rh[(R,R)-Me2trien]phi]3+ is shown on your left.

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Intercalation is stereoselective (for the Δ-Isomer), sequence specific (5'-TG(intercalator)CA-3') and regioselective (for the major groove of B-DNA).

C. L. Kielkopf, K. E. Erkkila, B. P. Hudson, J. K. Barton, D. C. Rees, Nature Structural Biology Vol 7., No. 2., 2000 p. 117-121. DOI
Structure of Λ-α-[Rh[(R,R)-Me2trien]phi]3+ and Δ-α-[Rh[(R,R)-Me2trien]phi]3+
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Resources developed by Marion E. Cass, Carleton College and updated in 2014. Computations and content done in consultation with Henry S. Rzepa, Imperial College, London