D. Research Applications:

2. Regioselectivity in Iron Uptake by E. Coli
Research by K. Raymond (University of California Berkeley)
b. Contrasting the ability of E. coli to recognize [Rh(III)Cat3]3-, [Rh(III)DMB3]3-, and [Fe(TRENCAM)]3-


The Raymond group synthesized and tested the ability of a number of differnent molecules to inhibit the iron uptake by E. coli. Here we show three of those molecules that together illustrate that recognition is regioselective to the metal tris chelate face of the molecule.
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Proposed Structure for &Delta-[Rh(III)Cat3]3-
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This molecule IS NOT recognized by the fep receptor
Reference: Ecker, D.J., Loomis, L.D., Cass, M.E.,
Raymond, K.N.; J. Am. Chem. Soc. Vol 110, 1988, 2457-2464. DOI
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This is the Proposed Structure for [&Delta-Rh(III)DMB3]3-
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This molecule IS recognized by the fep receptor
Reference: Ecker et al.
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This is the Known Structure for &Delta-[Fe(III)TRENCAM]3-
Reference/More information
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This molecule IS recognized by the fep receptor
Reference: Ecker et al.

These observations confirmed that recognition by the fep protein receptor was regioselective to the metal tris chelate region of the the molecules (which includes the three catechol binding subunits and some if not all of each amide linkage) and is highlighted for the naturally occurring Fe(ent)3-.

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