Example of a Research Application: J.Barton (2)

D. Research Applications:

1. Recognition of DNA structure using chiral metal chelates:
Research by Jacqueline K. Barton and Douglas C. Rees,
California Institute of Technology

b. The Crystal Structure of two oligomers of B-DNA with five intercalated molecules of &Delta -&alpha -[Rh[(R,R)-Me₂trien]phi]³⁺ is shown on your left.

Viewing tools:

Intercalation is stereoselective (for the &Delta Isomer), sequence specific (5'-TG(intercalator)CA-3') and regioselective (for the major groove of B-DNA).

C. L. Kielkopf, K. E. Erkkila, B. P. Hudson, J. K. Barton, D. C. Rees, Nature Structural Biology Vol 7., No. 2., 2000 p. 117-121. DOI
Structure of &Lambda - &alpha - [Rh[(R,R)-Me₂trien]phi]³⁺ and &Delta - &alpha - [Rh[(R,R)-Me₂trien]phi]³⁺

D. Research Applications:

1. Recognition of DNA structure using chiral metal chelates: Research by Jacqueline K. Barton and Douglas C. Rees, California Institute of Technology

b. The Crystal Structure of two oligomers of B-DNA with five intercalated molecules of &Delta -&alpha -[Rh[(R,R)-Me2trien]phi]3+ is shown on your left.

1. Recognition of DNA structure using chiral metal chelates:
Research by Jacqueline K. Barton and Douglas C. Rees,
California Institute of Technology

b. The Crystal Structure of two oligomers of B-DNA with five intercalated molecules of &Delta -&alpha -[Rh[(R,R)-Me₂trien]phi]³⁺ is shown on your left.