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Education and Professional Experience:
2007-Present: Professor of Chemistry,
Department of Chemistry, Carleton College, Northfield, MN (Department Chair:
2005-2008).
2008-2009: Visiting Scientist, Department of
Chemistry, University of Aarhus, Aarhus, Denmark. Research Group of Professor
Karl Anker Jørgensen.
2000-2007: Director of the Biochemistry
Concentration, Carleton College, Northfield, MN
1999-2007: Associate Professor of Chemistry,
Department of Chemistry, Carleton College, Northfield, MN.
1993-1998: Assistant Professor of Chemistry,
Carleton College, Northfield, MN.
1991 – 1993: Postdoctoral Fellow, Department
of Chemistry and Chemical Biology; Harvard
University, Cambridge, MA.
Research carried out in the laboratory of Professor Stuart L. Schreiber, involving the design and synthesis of analogs of cyclosporin A and their use as probes to study receptor-ligand interactions and cell signaling pathways.
1991: Ph.D. Organic Chemistry, University of California, Berkeley, CA
Thesis Title: "The Design, Synthesis, and Evaluation of Reaction Intermediate Analog Inhibitors of 5-Enolpyruvylshikimate-3-phosphate Synthase"
Research was carried out in the group of Professor Paul A. Bartlett, in the Department of Chemistry.
1985: B.A. Chemistry, Carleton College, Northfield, MN.
Publications:
Mohrig, J. R.; Alberg, D. G.; Hofmeister, G. E.; Schatz, P. F.; Hammond, C. N. Laboratory
Techniques in Organic Chemistry, 4th Ed., W. H. Freeman, New
York, 2014.
Duyzend, M. H.; Clark, C. T.; Simmons, S. L.; Johnson, W. B.;
Larson, A. M.; Leconte, A. M.; Wills, A. W.; Ginder-Vogel, M.; Wilhelm, A. K.; Czechowicz,
J. A.; Alberg, D. G. “Synthesis and Evaluation of Substrate Analogue
Inhibitors of Trypanothione Reductase”,
J. Enzyme Inhib.
Med. Chem. 2012, 27, 784-794. (Early
online publication: Nov. 15, 2011 (doi:10.3109/14756366.2011.604319)).
Prüger, B.; Hofmeister, G. E.;
Jacobsen, C. B.; Alberg, D. G.; Nielsen, M.; Jørgensen, K. A. “Transition-Metal-Free Formal Sonogashira Coupling and alpha-Carbonyl Arylation
Reactions”, Chem. Eur. J. 2010, 16,
3783-3790. DOI: 10.1002/chem.200902911.
Alberg, D. G; Poulsen,
T. B; Bertelsen, S.; Christensen, K. L.; Birkler, R. D.; Johannsen, M.; Jørgensen, K. A. "Organocatalysis
with Endogenous Compounds: Towards Novel Non-enzymatic Reactions", Bioorg. Med. Chem. Lett., 2009, 19, 3888-3891.
Mohrig, J. R.; Alberg, D. G.; Cartwright, C. H.; Pflum, M. K. H.; Aldrich, J. S.; Anderson, J. K.; Anderson,
S. R.; Fimmen, R. L.; Snover,
A. K. "Stereochemistry of 1,2-Elimination Reactions at the E2-E1cB
Interface–tert-Butyl
3-Tosyloxybutanoate and its Thioester", Org. and Biomol. Chem., 2008, 6, 1641-1646.
Funke, T.; Healy-Fried, M. L., Han, H.; Alberg, D. G.;
Bartlett, P. A; Schönbrunn, E., “Differential
Inhibition of Class I and Class II 5-Enolpyruvylshikimate-3-phosphate Synthases
by Tetrahedral Reaction Intermediate Analogues”, Biochemistry, 2007,
46, 13344-13351.
Czechowicz, J. A.; Wilhelm, A. K.; Spalding, M. D.; Larson, A.
M.; Engel, L. K.; Alberg, D. G, “The Synthesis and Inhibitory Activity of Dethiotrypanothione and Analogues against Trypanothione Reductase”, J. Org. Chem., 2007, 72, 3689-3693.
Priestman, M. A.; Healy, M. L.; Becker, A.; Alberg, D. G.;
Bartlett, P. A.; Lushington, G. H.; Schonbrunn, E. “Interaction of Phosphonate
Analogues of the Tetrahedral Reaction Intermediate with
5-Enolpyruvylshikimate-3-phosphate Synthase in Atomic Detail,” Biochemistry, 2005; 44; 3241-3248.
Garrard, E. A.; Borman,
E. C.; Cook, B. N.; Pike, E. J.; Alberg, D. G. "Inhibition of Trypanothione Reductase by
Substrate Analogues", Organic Letters, 2000, 2, 3639-3642.
Peter J. Belshaw,
Stephanie D. Meyer, Donna D. Johnson, Daniel Romo,
Yoshihara Ikeda, Merritt Andrus, David G. Alberg, L. Wayne Schultz, Jon Clardy, Stuart L. Schreiber, "Synthesis, Structure and
Mechanism in Immunophilin Research", SynLett 1994, 381-392.
Hengming Ke, Dale Mayrose, Peter J. Belshaw, David
G. Alberg, Stuart L. Schreiber, Zhi Yuh Chang, Felecia A. Etzkorn,
Susanna Ho and Christoper T. Walsh, "Crystal
Structures of Cyclophilin A Complexed
with Cyclosporin A and
N-Methyl-4-[(E)-2-butenyl]-4,4-dimethylthreonine Cyclosporin
A" Structure, 1994, 2, 33-44.
David G. Alberg and Stuart L. Schreiber,
"Structure-Based Design of a Cyclophilin-Calcineurin
Bridging Ligand", Science, 1993 262, 248-250.
Teresa Lyson, LeAnn
D. Ermel, Peter J. Belshaw,
David G. Alberg, Stuart L. Schreiber, and Ronald G. Victor, "Calcineurin as a Common Target Mediating Cyclosporin A and FK506 Induced Sympathetic Activation and
Acute Hypertension" Circulation Research., 1993, 73,
596-602.
Michael K. Rosen, Peter J. Belshaw, David G. Alberg, Stuart L. Schreiber, "The
Conformation of Cyclosporin A Bound to Cyclophilin is Altered (Once Again) Following Binding to Calcineurin: an Analysis of Receptor-Ligand-Receptor
Interactions," Bioorg. Med. Chem. Lett., 1992, 2, 747-751.
J. Liu, M. W. Albers, T. J. Wandless, S. Luan, D. G. Alberg, P. J. Belshaw,
P. Cohen, C. MacKintosh, C. B. Klee, and S. L.
Schreiber, "Inhibition of T Cell Signaling By Immunophilin-Ligand
Complexes Correlates with Loss of Calcineurin
Phosphatase Activity," Biochemistry, 1992, 31,
3896-3901.
David G. Alberg, Charles T. Lauhon, Robert Nyfeler, Alex Fässler, and Paul A. Bartlett, "Inhibition of EPSP
Synthase by Analogues of the Tetrahedral Intermediate and of EPSP," J.
Am. Chem. Soc., 1992, 114, 3535-3546.
Paul A. Bartlett, Kevin. L. McLaren, David G.
Alberg, Alex Fässler, Robert Nyfeler,
Charles T. Lauhon, and Charles B. Grissom,
"Exploration of the Shikimic Acid Pathway:
Opportunities for the Study of Enzyme Mechanisms through the Synthesis of
Intermediates and Inhibitors," in Prospects for Amino Acid Biosynthesis
Inhibitors in Crop Protection andPharmaceutical
Chemistry, L. G. Copping, Editor, Society of Chemical Industry; 1989, 155-170.
David G. Alberg and Paul A. Bartlett,
"Potent Inhibition of 5-Enolpyruvylshikimate-3-phosphate Synthase by a
Reaction Intermediate Analog," J. Am. Chem. Soc., 1989, 111,
2337-2338.
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