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David G. AlbergProfessor of Chemistry |
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Education:B.A. Chemistry, 1985 Ph.D. Chemistry, 1991 Postdoctoral Fellow, 1991-1993 |
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Organic Chemistry, Biological Chemistry, Advanced NMR Spectroscopy.
My research interests lie in bioorganic chemistry. My current research project involves the design, synthesis, and evaluation of potential inhibitors of the parasite enzyme trypanothione reductase (TR). The metabolic pathway involving TR is unique to the parasites of the genera Trypanosoma and Leishmania, which are responsible for many diseases affecting humans and domestic animals, including African sleeping sickness and Chaga's disease. We are curently synthesizing and evaluating a number of potential reversible and irreversible TR inhibitors which we expect to be selective for this enzyme over the closely related host enzyme, glutathione reductase.
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